Before starting the patient on Estragyn Vaginal Cream:

  • A complete physical examination including a blood pressure determination must be performed
  • Breasts and pelvic organs should be appropriately examined
  • Papanicolaou smear should be performed
  • Endometrial biopsy should be done only when indicated
  • Baseline tests should include mammography, measurements of blood glucose, calcium, triglycerides and cholesterol, and liver function tests

The importance of regular self-examination of the breasts should be discussed with the patient.

Follow-up examinations:

  • The first follow-up examination should be done within 3-6 months after initiation of treatment
  • Examinations should be made at intervals at least once a year

Non-medicinal ingredients of Estragyn Vaginal Cream are:

Arlacel 165, isopropyl myristate, methyl paraben, mineral oil, Peg 40 stearate, propyl paraben, sorbitan monostearate, stearic acid and water.


Estragyn Vaginal Cream is not suited for:

  • Pregnant Women: Estragyn Vaginal Cream should not be used during pregnancy (please see CONTRAINDICATIONS)
  • Nursing Women: Estragyn Vaginal Cream should not be used during lactation (please see CONTRAINDICATIONS)
  • Pediatrics (<16 years of age): Estragyn Vaginal Cream is not indicated for use in children

Dietary restrictions:

  • Patients should avoid grapefruit juice, a CYP3A4 inhibitor, as it may increase plasma concentrations of estrogens, possibly resulting in side effects
  • Patients should avoid acute alcohol ingestion during HRT as it may lead to elevations in circulating estradiol levels
  • Patients should avoid certain herbal products (e.g. St. John’s wort) which are available as over-the-counter (OTC) products, as they might interfere with steroid metabolism and therefore alter the efficacy and safety of estrogen/progestin products

Ask your patients about other non-prescription products, including herbal and natural products, concomitantly used with Estragyn Vaginal Cream.